反应详情

温度

100 °C

A mixture of 4-(4-phenylbutoxy)styrene (742 mg, 2.92 mmol), 2'-hydroxy-3'-iodoacetophenone (612 mg, 2.33 mmol), triethylamine (0.408 ml, 3.01 mmol), palladium (II) acetate (14 mg, 0.06 mmol) in acetonitrile (15 ml) was left under stirring at 100° C. for 24 h. Then the mixture was added with water (15 ml), extracted with ethyl ether (4×30 ml), dried and the solvents were evaporated off under reduced pressure. The resulting residue was purified by chromatography through a silica gel column, eluting with petroleum ether:ethyl ether, 9:1, recovering 633 g of the title compound (70% yield).

1. waitwas left
2. extractionextracted with ethyl ether (4×30 ml)
3. customdried
4. customthe solvents were evaporated off under reduced pressure
5. customThe resulting residue was purified by chromatography through a silica gel column
6. washeluting with petroleum ether