Phosphorus oxychloride → HCID 19606285, compound

HRID 1603930Notes

Reaction equation

HRID 1603930 reaction equation
[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][O:11][C:12]2[CH:17]=[CH:16][C:15](/[CH:18]=[CH:19]/[C:20]3[C:29]4[O:28][C:27]([C:30]([NH2:32])=O)=[CH:26][C:25](=[O:33])[C:24]=4[CH:23]=[CH:22][CH:21]=3)=[CH:14][CH:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.P(Cl)(Cl)(Cl)=O>CN(C=O)C>[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][O:11][C:12]2[CH:17]=[CH:16][C:15](/[CH:18]=[CH:19]/[C:20]3[C:29]4[O:28][C:27]([C:30]#[N:32])=[CH:26][C:25](=[O:33])[C:24]=4[CH:23]=[CH:22][CH:21]=3)=[CH:14][CH:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 19606305HCID 19606305, compound

Product 1

HCID 19606285HCID 19606285, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Following the process described in example 2 (point D), by reacting 8-[(E)-2-[4-(4-phenylbutoxy)phenyl]-ethen-1-yl]-4-oxo-4H-1-benzopyran-2-carboxamide with phosphorous oxychloride in DMF for 0.5 h at 0° C., the title compound was prepared (97% yield).

Workup

  1. customfor 0.5 h
  2. customat 0° C.

Sources & evidence

ORD record
ord-39efb2af8917449082bcc9ba44271f59
Source dataset
uspto-grants-1999_11
Patent number
US05990142

Reaction notes

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