Phosphorus oxychloride → HCID 19606335, compound

HRID 1603935Notes

Reaction equation

HRID 1603935 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][CH2:11][O:12][C:13]2[CH:18]=[CH:17][C:16](/[CH:19]=[CH:20]/[C:21]3[C:30]4[O:29][C:28]([C:31]([NH2:33])=O)=[CH:27][C:26](=[O:34])[C:25]=4[CH:24]=[CH:23][CH:22]=3)=[CH:15][CH:14]=2)=[CH:4][CH:3]=1.P(Cl)(Cl)(Cl)=O>CN(C=O)C>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][CH2:11][O:12][C:13]2[CH:18]=[CH:17][C:16](/[CH:19]=[CH:20]/[C:21]3[C:30]4[O:29][C:28]([C:31]#[N:33])=[CH:27][C:26](=[O:34])[C:25]=4[CH:24]=[CH:23][CH:22]=3)=[CH:15][CH:14]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 19606323HCID 19606323, compound

Product 1

HCID 19606335HCID 19606335, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Following the process described in example 2 (point D), reacting 8-[(E)-2-[4-[4-(4-fluorophenyl)butoxy]phenyl]ethen-1-yl]-4-oxo-4H-1-benzopyran-2-carboxamide with phosphorous oxychloride in DMF for 0.5 h at 0° C., the title compound was prepared (95% yield).

Workup

  1. customfor 0.5 h
  2. customat 0° C.

Sources & evidence

ORD record
ord-707cf75cc2624f589934f52657a01442
Source dataset
uspto-grants-1999_11
Patent number
US05990142

Reaction notes

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