L-Leucine → Alpha-Cyano-4-Hydroxycinnamic Acid

HRID 1604202Notes

Reaction equation

HRID 1604202 reaction equation
OP([O-])(O)=O.[K+].O=[CH:8][C@@H:9]([C@H:11]([C@@H:13]([C@@H:15]([CH2:17]O)O)[OH:14])O)O.[NH2:19][C@H:20](C(O)=O)CC(C)C.N[C@H:29]([C:36]([OH:38])=[O:37])[CH2:30]C1N=CNC=1>>[C:20]([C:29](=[CH:30][C:8]1[CH:9]=[CH:11][C:13]([OH:14])=[CH:15][CH:17]=1)[C:36]([OH:38])=[O:37])#[N:19]

Participants

5

Reactant 4

HCID 6106L-LeucineHCID 107526(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanalHCID 516951Monobasic potassium phosphateHCID 178419078HCID 178419078, compound

Product 1

HCID 2102Alpha-Cyano-4-Hydroxycinnamic Acid

Procedure

YNB-1 agar: 3.3 g/l KH2PO4, 16.7 g/l agar, pH adjusted to 7. Autoclaved for 20 min. at 121° C. After autoclaving, 25 ml of a 13.6% yeast nitrogen base without amino acids, 25 ml of a 40% glucose solution, 1.5 ml of a 1% L-leucine solution and 1.5 ml of a 1% histidine solution were added per 450 ml agar.

Sources & evidence

ORD record
ord-39f714c8ffba49c881633c2f45c00913
Source dataset
uspto-grants-1999_11
Patent number
US05994113

Reaction notes

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