Stannous chloride dihydrate → HCID 22008583, compound

HRID 1604313Notes

Reaction equation

HRID 1604313 reaction equation
[C:1]([C:4]1[CH:21]=[CH:20][C:7]([CH2:8][C:9]2[C:14]([Cl:15])=[CH:13][C:12]([N+:16]([O-])=O)=[CH:11][C:10]=2[Cl:19])=[CH:6][CH:5]=1)(=[O:3])[CH3:2].O.O.[Sn](Cl)Cl>C(OC(=O)C)C>[C:1]([C:4]1[CH:21]=[CH:20][C:7]([CH2:8][C:9]2[C:14]([Cl:15])=[CH:13][C:12]([NH2:16])=[CH:11][C:10]=2[Cl:19])=[CH:6][CH:5]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 61436Stannous chloride dihydrateHCID 22008563HCID 22008563, compound

Product 1

HCID 22008583HCID 22008583, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

In 11 ml of ethylacetate were dissolved 1.1 g 4-(4-Acetylbenzyl)-3,5-dichloronitrobenzene and 3.8 g Tin (11) chloride dihydrate. The solution was allowed to proceed for one hour at temperatures ranging from 40-50° C. After completion of the reaction. The reaction mixture was poured into 100 ml ice-water, followed by extraction with 150 ml ethylacetate. The extract was washed with water and 25% ammonia solution, dried over anhydrous magnesium sulfate, and concentrated to afford the titled compound in a yield of 100%, m.p. 97-98° C.

Workup

  1. customranging from 40-50° C
  2. customAfter completion of the reaction
  3. extractionfollowed by extraction with 150 ml ethylacetate
  4. washThe extract was washed with water and 25% ammonia solution
  5. dry with materialdried over anhydrous magnesium sulfate
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-f067d4cbdfc24039846b3275853d4736
Source dataset
uspto-grants-1999_11
Patent number
US05994355

Reaction notes

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