反应详情

In 7 ml of ethyl acetate was dissolved 0.7 g of 2-[4-(4-acetylbenzyl)-3,5-dichlorophenyl]-1-benzylidene-4-(2,2-dimethoxyethyl)semicarbazide. To the solution was added 0.27 g of 35% hydrochloric acid. The mixture was stirred for one hour at room temperature. The reaction mixture was washed with water, dried and concentrated. The residue was purified by column chromatography (Merck Silica Gel 60; normalhexane-ethylacetate=1:3) to provide 0.24 g of the title compound. m.p. 189-190° C.

1. washThe reaction mixture was washed with water
2. customdried
3. concentrationconcentrated
4. customThe residue was purified by column chromatography (Merck Silica Gel 60; normalhexane-ethylacetate=1:3)