Dichloromethane → Tert-butyl 3-(4-cyano-2,6-dimethylphenyl)propanoate

HRID 160432Notes

Reaction equation

HRID 160432 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([CH2:7][CH2:8][c:9]1[c:10]([CH3:19])[cH:11][c:12]([C:16]([NH2:17])=[O:18])[cH:13][c:14]1[CH3:15])=[O:20].[CH3:21][CH2:22][N:23]([CH2:24][CH3:25])[CH2:26][CH3:27].[Cl:41][CH2:42][Cl:43].[F:28][C:29]([F:30])([F:31])[C:32]([O:33][C:34](=[O:35])[C:36]([F:37])([F:38])[F:39])=[O:40]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([CH2:7][CH2:8][c:9]1[c:10]([CH3:19])[cH:11][c:12]([C:16]#[N:17])[cH:13][c:14]1[CH3:15])=[O:20]

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 9845Trifluoroacetic anhydrideHCID 11849882Tert-butyl 3-(2,6-dimethyl-4-carbamoylphenyl)propanoate

Product 1

HCID 66935544Tert-butyl 3-(4-cyano-2,6-dimethylphenyl)propanoate

Sources & evidence

ORD record
ord-6b84dc6959b644689550ad04e7139633
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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