Morpholine → MOBS

HRID 1604346Notes

Reaction equation

HRID 1604346 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[CH2:7]1[CH2:14][O:13][S:10](=[O:12])(=[O:11])[CH2:9][CH2:8]1>C(O)(C)C>[N:1]1([CH2:14][CH2:7][CH2:8][CH2:9][S:10]([OH:13])(=[O:12])=[O:11])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 154111,4-Butane sultone

Product 1

HCID 3674064MOBSYield 18%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Morpholine (3.56 g) was dissolved in isopropanol (25 ml) and treated with 1,4-butane sultone (5.58 g) at 10° C. The reaction mixture was allowed to warm to room temperature and stirred for 3 days. The white precipitate that had formed was filtered and dried to give the title compound (1.64 g).

Workup

  1. customThe white precipitate that had formed
  2. filtrationwas filtered
  3. customdried

Sources & evidence

ORD record
ord-67d5c0bff0d744d4baa38c5306c6263c
Source dataset
uspto-grants-1999_11
Patent number
US05994344

Reaction notes

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