4-Chlorophenol → HCID 22622545, compound

HRID 1604381Notes

Reaction equation

HRID 1604381 reaction equation
[CH2:1]([NH:3][C:4]1[N:9]=[N:8][C:7]([C:10]([O:12][CH2:13][CH2:14][CH2:15][CH3:16])=[O:11])=[CH:6][CH:5]=1)[CH3:2].[Cl:17][C:18]1[CH:23]=C[C:21]([OH:24])=[CH:20][CH:19]=1.F[C:26](F)(F)[C:27](O)=O>>[Cl:17][C:18]1[CH:19]=[CH:20][C:21]([OH:24])=[C:2]([CH:23]=1)[CH2:1][N:3]([C:4]1[N:9]=[N:8][C:7]([C:10]([O:12][CH2:13][CH2:14][CH2:15][CH3:16])=[O:11])=[CH:6][CH:5]=1)[CH2:26][CH3:27]

Participants

4

Reactant 3

HCID 46844-ChlorophenolHCID 6422Trifluoroacetic acidHCID 22622555HCID 22622555, compound

Product 1

HCID 22622545HCID 22622545, compound

Procedure

The title compound was prepared from butyl 6-(ethylamino)pyridazine-3-carboxylate and 4-chlorophenol using a similar method to that of reference example 3, except 0.4 equivalents of trifluoroacetic acid were added to the reaction mixture.

Sources & evidence

ORD record
ord-69fa14dfdc3847e3bdd13e30929421e4
Source dataset
uspto-grants-1999_11
Patent number
US05994353

Reaction notes

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