Dichloromethane → 5-bromo-3-(2-trifluoromethoxy-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazolo[3,4-b]pyridine

HRID 160462Notes

Reaction equation

HRID 160462 reaction equation
[Br:1][c:2]1[cH:3][c:4]2[c:5]([n:6][cH:7]1)[n:8]([CH2:12][O:13][CH2:14][CH2:15][Si:16]([CH3:17])([CH3:18])[CH3:19])[n:9][c:10]2[I:11].[CH2:37]1[O:38][CH2:39][CH2:40][CH2:41]1.[Cl:34][CH2:35][Cl:36].[F:20][C:21]([O:22][c:23]1[c:24]([B:29]([OH:30])[OH:31])[cH:25][cH:26][cH:27][cH:28]1)([F:32])[F:33]>>[Br:1][c:2]1[cH:3][c:4]2[c:5]([n:6][cH:7]1)[n:8]([CH2:12][O:13][CH2:14][CH2:15][Si:16]([CH3:17])([CH3:18])[CH3:19])[n:9][c:10]2-[c:24]1[c:23]([O:22][C:21]([F:20])([F:32])[F:33])[cH:28][cH:27][cH:26][cH:25]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 8028TetrahydrofuranHCID 27772042-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride)HCID 598361345-bromo-3-iodo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazolo[3,4-b]pyridine

Product 1

HCID 579758215-bromo-3-(2-trifluoromethoxy-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazolo[3,4-b]pyridine

Sources & evidence

ORD record
ord-2d1c41415fb14a908c49f5675cc2e9d0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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