ethyl (E)-3-[2-(4-tert-butylthiazol-2-yl)benzofuran-5-yl]propenoate → Ethyl 3-[2-(4-tert-butylthiazol-2-yl)benzofuran-5-yl]propionate

HRID 1604635Notes

Reaction equation

HRID 1604635 reaction equation
[C:1]([C:5]1[N:6]=[C:7]([C:10]2[O:11][C:12]3[CH:18]=[CH:17][C:16](/[CH:19]=[CH:20]/[C:21]([O:23][CH2:24][CH3:25])=[O:22])=[CH:15][C:13]=3[CH:14]=2)[S:8][CH:9]=1)([CH3:4])([CH3:3])[CH3:2]>O1CCCC1>[C:1]([C:5]1[N:6]=[C:7]([C:10]2[O:11][C:12]3[CH:18]=[CH:17][C:16]([CH2:19][CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22])=[CH:15][C:13]=3[CH:14]=2)[S:8][CH:9]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 1

HCID 86754881ethyl (E)-3-[2-(4-tert-butylthiazol-2-yl)benzofuran-5-yl]propenoate

Product 1

HCID 19603662Ethyl 3-[2-(4-tert-butylthiazol-2-yl)benzofuran-5-yl]propionateYield 99.4%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of ethyl (E)-3-[2-(4-tert-butylthiazol-2-yl)-benzofuran-5-yl-]propenoate (0.65 g) in tetrahydrofuran (10 ml) was hydrogenated over 10% Pd--C (0.1 g) at room temperature under atmospheric pressure. After removal of the catalyst by filtration the filtrate was concentrated under reduced pressure to give ethyl 3-[2-(4-tert-butylthiazol-2-yl)benzofuran-5-yl]propionate (0.65 g).

Workup

  1. customAfter removal of the catalyst
  2. filtrationby filtration the filtrate
  3. concentrationwas concentrated under reduced pressure

Sources & evidence

ORD record
ord-bbfc218121b8439385134455d9d025d2
Source dataset
uspto-grants-1999_11
Patent number
US05994378

Reaction notes

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