反应详情

温度

50 °C

Levobupivacaine (S,S)-tartrate (50 g, 0.069 mol) was suspended in isopropanol (150 ml) and heated to 50° C. Hydrogen chloride (5 g, 0.14 mol) gas was introduced. The temperature rose to 65° C. and the solids dissolved. The mixture was heated to 80° C. to ensure complete dissolution. The mixture was cooled to 5° C. and a solid crystallised. The solid was filtered off and washed with isopropanol (2×50 ml) and dried in vacuo to give levobupivacaine hydrochloride (21.9 g, 40%).

1. customrose to 65° C.
2. dissolutionthe solids dissolved
3. temperatureThe mixture was heated to 80° C.
4. dissolutiondissolution
5. temperatureThe mixture was cooled to 5° C.
6. customa solid crystallised
7. filtrationThe solid was filtered off
8. washwashed with isopropanol (2×50 ml)
9. customdried in vacuo