Hydrogen Peroxide → HCID 131710120, compound

HRID 1604870Notes

Reaction equation

HRID 1604870 reaction equation
Cl.[Cl:2][C:3]1[C:9](=[O:10])[N:8]([CH2:11][CH2:12][N:13]([CH3:15])[CH3:14])[C:7]2[CH:16]=[CH:17][CH:18]=[CH:19][C:6]=2[S:5][C:4]=1[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.[OH:26]O>C(O)(=O)C>[ClH:2].[Cl:2][C:3]1[C:9](=[O:10])[N:8]([CH2:11][CH2:12][N:13]([CH3:15])[CH3:14])[C:7]2[CH:16]=[CH:17][CH:18]=[CH:19][C:6]=2[S:5](=[O:26])[C:4]=1[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 131710121HCID 131710121, compound

Product 1

HCID 131710120HCID 131710120, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

3-Chloro-5-[2-(dimethylamino)ethyl]-2-phenyl-1,5-benzothiazepin-4(5H)-one, hydrochloride (prepared as described in Example 1) is treated with one equivalent of hydrogen peroxide in dilute acetic acid, and allowed to stand for about 16 hours. Solvent removal yields the title compound.

Workup

  1. customSolvent removal

Sources & evidence

ORD record
ord-3a6f266433fd471485ffa9c6df3da035
Source dataset
uspto-grants-1976_04
Patent number
US03948889

Reaction notes

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