Hydrochloric Acid → AGN-PC-0NICCC

HRID 1604983Notes

Reaction equation

HRID 1604983 reaction equation
[ClH:1].[O:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[C:4]([CH2:11][C:12](=[NH:16])OCC)=[N:3]1.[CH2:17](N)[CH2:18][NH2:19].Cl>C(O)C>[ClH:1].[NH:19]1[CH2:18][CH2:17][N:16]=[C:12]1[CH2:11][C:4]1[C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=2[O:2][N:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3301EthylenediamineHCID 12786149HCID 12786149, compound

Product 1

HCID 12279087AGN-PC-0NICCCYield 93.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In ethanol (10 ml) was dissolved ethyl 1,2-benzisoxazole-3-acetimidate hydrochloride (2.0 g) and thereto was added ethylenediamine (0.6 g) under ice-cooling and the mixture was allowed to stand at 5°C overnight. To the mixture was added ethanolic hydrochloric acid and the precipitated crystallines were separated by filtration and recrystallized from ethanol to give the desired compound (1.85 g). m.p. 223° to 228°C.

Workup

  1. temperaturecooling
  2. customthe precipitated crystallines were separated by filtration
  3. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-0481f6b948d249ea98299821104a247b
Source dataset
uspto-grants-1976_04
Patent number
US03948928

Reaction notes

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