Acetyl chloride → HCID 12251780, compound

HRID 1605018Notes

Reaction equation

HRID 1605018 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]1[CH:15]=[C:14]([C:16]2[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=2)[NH:13][N:12]=1)([O:3][CH3:4])=[O:2].[H-].[Na+].[C:26](Cl)(=[O:28])[CH3:27]>O1CCCC1>[C:26]([N:13]1[C:14]([C:16]2[CH:17]=[CH:18][C:19]([O:22][CH3:23])=[CH:20][CH:21]=2)=[CH:15][C:11]([C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[C:1]([O:3][CH3:4])=[O:2])=[N:12]1)(=[O:28])[CH3:27]

Participants

5

Reactant 3

HCID 6367Acetyl chlorideHCID 24758Sodium hydrideHCID 178497612HCID 178497612, compound

Product 1

HCID 12251780HCID 12251780, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 30 g 3-(2-carbomethoxyphenyl)-5-(4-methoxyphenyl)pyrazole, 0.30 g sodium hydride and 0.8 g acetyl chloride in 50 ml anhydrous tetrahydrofuran (THF) is stirred and refluxed overnight. The reaction mixture is filtered and the THF is removed from the filtrate to yield 1-acetyl-3-(2-carbomethoxyphenyl)-5-(4-methoxyphenyl)pyrazole.

Workup

  1. temperaturerefluxed overnight
  2. filtrationThe reaction mixture is filtered
  3. customthe THF is removed from the filtrate

Sources & evidence

ORD record
ord-e97b330e37474968a0c9b19b4b4054f3
Source dataset
uspto-grants-1976_04
Patent number
US03948937

Reaction notes

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