3,4,5,6-Tetrahydrophthalic anhydride → Disodium

HRID 1605021Notes

Reaction equation

HRID 1605021 reaction equation
[C:1]1(=[O:11])[O:6][C:4](=[O:5])[C:3]2[CH2:7][CH2:8][CH2:9][CH2:10][C:2]1=2.C[O-].[Na+:14].[Na:15][CH2:16][C:17]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:18]>CN(C)C=O>[Na:14][Na:15].[C:17]([CH2:16][C:4]([C:3]1[CH2:7][CH2:8][CH2:9][CH2:10][C:2]=1[C:1]([OH:6])=[O:11])=[O:5])(=[O:18])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

6

Reactant 3

HCID 124753,4,5,6-Tetrahydrophthalic anhydrideHCID 10942334Sodium MethoxideHCID 178521073HCID 178521073, compound

Product 2

HCID 141233DisodiumHCID 21400851HCID 21400851, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 30.4 g of 3,4,5,6-tetrahydrophthalic anhydride in 150 ml of dimethylformamide is added 11.0 g of sodium methoxide. After one-half hour this mixture is introduced into the sodio-acetophenone solution. The resulting mixture is stirred at 120° for 3 hours; the solid precipitate is filtered off, washed with acetone and ether, and dried to yield the crude disodium salt of 2-benzoylacetyl-1-cyclohexenecarboxylic acid.

Workup

  1. filtrationthe solid precipitate is filtered off
  2. washwashed with acetone and ether
  3. customdried

Sources & evidence

ORD record
ord-1f83ec9077a24ee78d74374a71cc8424
Source dataset
uspto-grants-1976_04
Patent number
US03948937

Reaction notes

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