Sodium Hydroxide → HCID 21548938, compound

HRID 1605053Notes

Reaction equation

HRID 1605053 reaction equation
[CH:1]1[C:14]2[CH2:13][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[O:6][C:5]=2[CH:4]=[CH:3][C:2]=1[CH:15]([CH3:19])[C:16](O)=[O:17].[H-].[H-].[H-].[H-].[Li+].[Al+3].[OH-].[Na+]>C1COCC1.O>[CH:1]1[C:14]2[CH2:13][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[O:6][C:5]=2[CH:4]=[CH:3][C:2]=1[CH:15]([CH3:19])[CH2:16][OH:17]

Participants

6

Reactant 3

HCID 14798Sodium HydroxideHCID 12274162HCID 12274162, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 21548938HCID 21548938, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent3×

Procedure

A solution of 2.54 g. of 2-(2-xanthenyl)-propionic acid in 20 ml. of absolute THF is added dropwise to a mixture of 0.57 g. of LiAlH4 in 20 ml. of absolute THF. The mixture is refluxed for 8 hours, 2 ml. of water in 3 ml. of THF, as well as 4 ml. of 25% sodium hydroxide solution are added thereto, the mixture is decanted and the residue washed with ether. After the drying, filtration, and evaporation of the combined organic phases, 2-(2-xanthenyl)-propanol is obtained, m.p. 86°-89°.

Workup

  1. temperatureThe mixture is refluxed for 8 hours
  2. customthe mixture is decanted
  3. washthe residue washed with ether
  4. filtrationAfter the drying, filtration, and evaporation of the combined organic phases

Sources & evidence

ORD record
ord-2575f86e30b2439f9ab5db471fad716e
Source dataset
uspto-grants-1976_04
Patent number
US03948949

Reaction notes

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