Methylamine → HCID 21549476, compound

HRID 1605150Notes

Reaction equation

HRID 1605150 reaction equation
O=[C:2]([CH3:10])[CH2:3][CH2:4][N:5]1[CH:9]=[CH:8][N:7]=[CH:6]1.[CH3:11][NH2:12]>[Pt]=O.C(O)C>[CH3:11][NH:12][CH:2]([CH3:10])[CH2:3][CH2:4][N:5]1[CH:9]=[CH:8][N:7]=[CH:6]1

Participants

5

Reactant 2

HCID 6329MethylamineHCID 47375664-Imidazol-1-yl-butan-2-one

Product 1

HCID 21549476HCID 21549476, compound

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 702EthanolSolvent2×

Procedure

A suspension of 0.35 g. of platinum oxide in 30 ml. of absolute ethanol is hydrogenated at 50 p.s.i. for one hour. To this is added a mixture of 13.8 g. of 1-(3-oxobutyl)-imidazole, 6.2 g. of methylamine and 60 ml. of ethanol. The mixture is shaken under ca. 50 p.s.i. of hydrogen until one equivalent is absorbed. Filtration of the catalyst and removal of solvent in vacuo gives 1-(3-methylaminobutyl)-imidazole.

Workup

  1. additionA suspension of 0.35 g
  2. additionTo this is added
  3. additiona mixture of 13.8 g
  4. customof hydrogen until one equivalent is absorbed
  5. filtrationFiltration of the catalyst and removal of solvent in vacuo

Sources & evidence

ORD record
ord-a624fef46c3b4f639d5123d78b33654d
Source dataset
uspto-grants-1976_04
Patent number
US03949076

Reaction notes

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