Hydrochloric Acid → 4-Aminobenzophenone

HRID 1605172Notes

Reaction equation

HRID 1605172 reaction equation
[C:1]([C:9]1[CH:18]=[CH:17][C:12]([NH:13]C(=O)C)=[CH:11][CH:10]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[OH-].[Na+]>>[NH2:13][C:12]1[CH:11]=[CH:10][C:9]([C:1]([C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[O:8])=[CH:18][CH:17]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 228532N-(4-benzoylphenyl)acetamide

Product 1

HCID 143464-Aminobenzophenone

Procedure

p-Benzoylacetanilide (2.8 g.) and 100 ml. of 1N hydrochloric acid are refluxed for six hours. After cooling, the solution is made alkaline by the addition of 2N sodium hydroxide solution and extracted with ether to give 4-aminobenzophenone, which is recrystallized from methanol.

Workup

  1. temperatureAfter cooling
  2. extractionextracted with ether

Sources & evidence

ORD record
ord-a72f84d7ffd64c59ba1cab791580eabc
Source dataset
uspto-grants-1976_04
Patent number
US03949084

Reaction notes

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