反应详情

To a solution of 16.8 g. (0.2 mole) of sodium bicarbonate in 300 ml of water was added 22.8 g.(0.2 mole) of 6-methyl-2-thiouracil. The mixture was heated on a steam bath for 10 minutes. To this mixture was then added 18.6 g.(0.2 mole) of 2-chloroacetamide followed by 100 ml of absolute ethanol. The mixture was heated on a steam bath for 2 hours. The solution was cooled in an ice bath and the precipitate which formed was collected and recrystallized from a mixture of N,N-dimethylformamide and ethanol to afford 8 g. of product, m.p. 238°-240° d.

1. temperatureThe mixture was heated on a steam bath for 10 minutes
2. additionTo this mixture was then added 18.6 g
3. temperatureThe mixture was heated on a steam bath for 2 hours
4. temperatureThe solution was cooled in an ice bath
5. customthe precipitate which formed
6. customwas collected
7. customrecrystallized from a mixture of N,N-dimethylformamide and ethanol
8. customto afford 8 g