反应详情

To a solution of 19.4 g. (0.13 mole) of N,N-diethylaniline in 250 ml of phosphorus oxychloride was added 25.8 g (0.13 mole) of 2-(4-hydroxy-6-methyl-2-pyrimidinylthio)acetamide, the mixture was heated under reflux for 1 hour. The phosphorus oxychloride was removed in a rotary evaporator and the residue was poured onto 1 liter of cracked ice. The precipitate which resulted was collected, dried, and recrystallized from heptane to give 13.0 g. of pure white product, m.p. 62°-65°.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 1 hour
3. customThe phosphorus oxychloride was removed in a rotary evaporator
4. additionthe residue was poured onto 1 liter of cracked ice
5. customThe precipitate which resulted
6. customwas collected
7. customdried
8. customrecrystallized from heptane
9. customto give 13.0 g