反应详情

A mixture of 6.20 g. (0.02 mole) of (4-methyl-6-piperonylamino-2-pyrimidinylthio)acetonitrile, 2.76 g. (0.04 mole) of hydroxylamine hydrochloride and 8.48 g. (0.08 mole) of sodium carbonate in 100 ml of N,N-dimethylformamide was heated on a steam bath for four hours. The mixture was filtered and the filtrate was evaporated in a rotary evaporator. The residue was triturated with ether and the insoluble material was collected and recrystallized from a mixture of ethanol-N,N-dimethylacetamide to give 3.5 g. of product, m.p. 190°-192° dec.

1. additionA mixture of 6.20 g
2. filtrationThe mixture was filtered
3. customthe filtrate was evaporated in a rotary evaporator
4. customThe residue was triturated with ether
5. customthe insoluble material was collected
6. customrecrystallized from a mixture of ethanol-N,N-dimethylacetamide
7. customto give 3.5 g