Hydrochloric Acid → HCID 20319037, compound

HRID 1605607Notes

Reaction equation

HRID 1605607 reaction equation
[NH2:1][C:2]1[C:11]([Br:12])=[CH:10][C:9]([C:13]([O:15]C)=[O:14])=[CH:8][C:3]=1[CH2:4][NH:5][CH2:6][CH3:7].[ClH:17]>>[ClH:17].[NH2:1][C:2]1[C:11]([Br:12])=[CH:10][C:9]([C:13]([OH:15])=[O:14])=[CH:8][C:3]=1[CH2:4][NH:5][CH2:6][CH3:7]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 53728375HCID 53728375, compound

Product 1

HCID 20319037HCID 20319037, compound

Conditions

Temperature
-15 °C

Procedure

2.7 gm of 2-amino-3-bromo-5-carbomethoxy-N-ethyl-benzylamine were boiled for 35 minutes with 65 ml of 6 N hydrochloric acid. Thereafter, upon cooling the reaction solution to -15°C, N-ethyl-2-amino-3-bromo-5-carboxy-benzylamine hydrochloride crystallized out and was recrystallized from ethanol/ether, whereupon it had a melting point of 261°C (decomp.).

Workup

  1. customN-ethyl-2-amino-3-bromo-5-carboxy-benzylamine hydrochloride crystallized out
  2. customwas recrystallized from ethanol/ether, whereupon it

Sources & evidence

ORD record
ord-454c258012f048a4a714c14a1f5daad4
Source dataset
uspto-grants-1976_04
Patent number
US03950393

Reaction notes

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