Methane → HCID 20351855, compound

HRID 1605608Notes

Reaction equation

HRID 1605608 reaction equation
[NH2:1][C:2]1[CH:18]=[CH:17][C:16]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:15][C:3]=1[CH2:4][N:5](CC1C=CC=CC=1)[CH2:6][CH3:7].[H][H].C.[ClH:27]>CO>[ClH:27].[NH2:1][C:2]1[CH:18]=[CH:17][C:16]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:15][C:3]=1[CH2:4][NH:5][CH2:6][CH3:7]

Participants

6

Reactant 4

HCID 297MethaneHCID 313Hydrochloric AcidHCID 20351866HCID 20351866, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 20351855HCID 20351855, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

3.8 gm of 2-amino-N-benzyl-5-carbethoxy-N-ethyl-benzylamine were hydrogenated in a mixture of 50 ml of methanol and 1 ml of concentrated hydrochloric acid at room temperature and at a hydrogen pressure of 5 atmospheres in the presence of palladized charcoal. Then, the catalyst was filtered off, and the filtrate was evaporated to dryness in vacuo. The residue was recrystallized from ethanol by addition of ether, yielding 2-amino-5-carbethoxy-N-ethyl-benzylamine hydrochloride, m.p. 173°-176°C (decomp.).

Workup

  1. filtrationThen, the catalyst was filtered off
  2. customthe filtrate was evaporated to dryness in vacuo
  3. customThe residue was recrystallized from ethanol by addition of ether

Sources & evidence

ORD record
ord-7ccc2003a4e946df86976bf86fa662bb
Source dataset
uspto-grants-1976_04
Patent number
US03950393

Reaction notes

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