Hydrochloric Acid → ((2-Aminoethyl)thio)acetic acid, methyl ester, hydrochloride

HRID 1605700Notes

Reaction equation

HRID 1605700 reaction equation
[NH2:1][CH2:2][CH2:3][S:4][CH2:5][C:6]([OH:8])=[O:7].[CH3:9]OC(OC)(C)C.[ClH:16]>CO>[ClH:16].[CH3:9][O:7][C:6]([CH2:5][S:4][CH2:3][CH2:2][NH2:1])=[O:8]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 64952,2-DimethoxypropaneHCID 4474780HCID 4474780, compound

Product 1

HCID 170337((2-Aminoethyl)thio)acetic acid, methyl ester, hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

13.5 g of S-(β-aminoethyl)mercaptoacetic acid and 10.8 g of 2,2-dimethoxy propane are added, successively, to a solution of 7.3 g of gaseous hydrochloric acid in 20 cc of methanol. The solution is permitted to stand for 12 hours at ambient temperature. The flasks formed (17.5 g) are filtered and washed with ethyl acetate. Fusion point = 100°C.

Workup

  1. customThe flasks formed (17.5 g)
  2. filtrationare filtered
  3. washwashed with ethyl acetate
  4. customFusion point = 100°C.

Sources & evidence

ORD record
ord-a0530f880b44499f94c6a41b7cd8a9ac
Source dataset
uspto-grants-1976_04
Patent number
US03950542

Reaction notes

Loading…