Water → HCID 20355333, compound

HRID 1605920Notes

Reaction equation

HRID 1605920 reaction equation
[OH:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10]3=[CH:12][S:13][CH:14]=[C:9]3[C:8](SC)=[N:7][C:6]=2[CH:17]=1.O.[C:19]1([N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>C(O)(=O)C>[OH:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10]3=[CH:12][S:13][CH:14]=[C:9]3[C:8]([N:28]3[CH2:29][CH2:30][N:25]([C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=4)[CH2:26][CH2:27]3)=[N:7][C:6]=2[CH:17]=1

Participants

5

Reactant 3

HCID 962WaterHCID 70961-PhenylpiperazineHCID 20355330HCID 20355330, compound

Product 1

HCID 20355333HCID 20355333, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 7-hydroxy-10-(methylthio)-4H-thieno[3,4-b][1,5]benzodiazepine in excess N-phenylpiperazine and glacial acetic acid is heated at 140°-160°C. for 2 days. The solution is poured into water and the product is collected.

Workup

  1. customthe product is collected

Sources & evidence

ORD record
ord-270b8257bd1345f7bdf40307936ab722
Source dataset
uspto-grants-1976_04
Patent number
US03951981

Reaction notes

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