Diethyl (ethoxymethylene)malonate → Diethyl (3-methoxycarbonyl-4-methylthienyl)aminomethylenemalonate

HRID 1605968Notes

Reaction equation

HRID 1605968 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH3:11])[C:6]=1[C:7]([O:9][CH3:10])=[O:8].C(O[CH:15]=[C:16]([C:22]([O:24][CH2:25][CH3:26])=[O:23])[C:17]([O:19][CH2:20][CH3:21])=[O:18])C>>[CH3:10][O:9][C:7]([C:6]1[C:5]([CH3:11])=[CH:4][S:3][C:2]=1[NH:1][CH:15]=[C:16]([C:17]([O:19][CH2:20][CH3:21])=[O:18])[C:22]([O:24][CH2:25][CH3:26])=[O:23])=[O:8]

Participants

3

Reactant 2

HCID 6871Diethyl (ethoxymethylene)malonateHCID 2759773Methyl 2-amino-4-methylthiophene-3-carboxylate

Product 1

HCID 13217727Diethyl (3-methoxycarbonyl-4-methylthienyl)aminomethylenemalonate

Procedure

Reaction of methyl 2-amino-4-methylthiophene-3-carboxylate with diethyl ethoxymethylenemalonate in a manner similar to that used in Reference Example 10 yields diethyl (3-methoxycarbonyl-4-methylthienyl)aminomethylenemalonate as crystals melting at 105.5°-106°C.

Sources & evidence

ORD record
ord-e9e3152360a14acd819c8104e586717c
Source dataset
uspto-grants-1976_04
Patent number
US03951989

Reaction notes

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