Tetrahydrofuran → HCID 20354901, compound

HRID 1606083Notes

Reaction equation

HRID 1606083 reaction equation
[CH2:1]([S:5]([C:8]1[N:12]=[CH:11][NH:10][N:9]=1)(=[O:7])=[O:6])[CH:2]([CH3:4])[CH3:3].[CH2:13]([N:16]([CH2:20][CH2:21][CH3:22])[C:17](Cl)=[O:18])[CH2:14][CH3:15].C(N(CC)CC)C.O1CCCC1>CCOCC>[CH2:13]([N:16]([CH2:20][CH2:21][CH3:22])[C:17]([N:10]1[CH:11]=[N:12][C:8]([S:5]([CH2:1][CH:2]([CH3:4])[CH3:3])(=[O:6])=[O:7])=[N:9]1)=[O:18])[CH2:14][CH3:15]

Participants

6

Reactant 4

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 3015348Dipropylcarbamoyl chlorideHCID 178455593HCID 178455593, compound

Product 1

HCID 20354901HCID 20354901, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A mixture of 9.5 g. 3-isobutylsulphonyl-1,2,4-triazole, 8.2 g. dipropylcarbamoyl chloride, 7.5 ml. dry triethylamine and 100 ml. dry tetrahydrofuran was refluxed under anhydrous conditions for 11 hours. The reaction mixture was worked up as described in Example 1, using ether in place of methylene dichloride, to give 1-dipropylcarbamoyl-3-isobutylsulphonyl-1,2,4-triazole, m.p. 62° - 63.5°C. (from petroleum ether, b.p. 62° - 68°C.).

Workup

  1. additionA mixture of 9.5 g

Sources & evidence

ORD record
ord-e20672206df0429ba67d20887d7162a6
Source dataset
uspto-grants-1976_04
Patent number
US03952001

Reaction notes

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