Dichloromethane → HCID 571485, compound

HRID 1606260Notes

Reaction equation

HRID 1606260 reaction equation
[C:1]([NH:4][C:5]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)(SC)[C:6]([O:8][CH3:9])=[O:7])(=[O:3])[CH3:2].C1(S)C=CC=CC=1.C(N(CC)CC)C.C(Cl)Cl>CO>[C:1]([NH:4][CH:5]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:6]([O:8][CH3:9])=[O:7])(=[O:3])[CH3:2]

Participants

6

Reactant 4

HCID 6344DichloromethaneHCID 7969ThiophenolHCID 8471TriethylamineHCID 24972452HCID 24972452, compound

Product 1

HCID 571485HCID 571485, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

113 Milligrams of methyl α-acetylamino-α-methylthiophenylacetate and 41 mg of thiophenol were dissolved in 5 ml of methanol, and to the solution 0.5 ml of triethylamine was added, followed by an hour's refluxing. After a reduced pressure concentration of the reaction mixture, the residue was parted by a column chromatography (silica gel and methylene chloride). Thus 92 mg of methyl α-acetylaminophenylacetate was obtained. The yield was 99%.

Workup

  1. waitfollowed by an hour
  2. temperature's refluxing

Sources & evidence

ORD record
ord-a04ad117e8cc483c976bcf4665d38ffd
Source dataset
uspto-grants-1976_04
Patent number
US03952044

Reaction notes

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