m-Chloroperbenzoic acid → 5-Benzyloxy-2-methylpyridine 1-oxide

HRID 1606305Notes

Reaction equation

HRID 1606305 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([CH3:15])=[N:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.ClC1C=CC=C(C(OO)=[O:24])C=1>C(Cl)(Cl)Cl>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([CH3:15])=[N+:13]([O-:24])[CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 70297m-Chloroperbenzoic acidHCID 123972515-(Benzyloxy)-2-methylpyridine

Product 1

HCID 123972525-Benzyloxy-2-methylpyridine 1-oxide

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A solution of 38.1 g. (0.1915 mol) of 5-benzyloxy-2-methylpyridine in 1 l. of chloroform is treated at 25°C. with 42.7 g. of 85% m-chloroperbenzoic acid. Ater one hour the solution is washed with 5% aqueous sodium carbonate, water, dried and evaporated to give 5-benzyloxy-2-methylpyridine-N-oxide, m.p. 87°-89°C.

Workup

  1. washAter one hour the solution is washed with 5% aqueous sodium carbonate, water
  2. customdried
  3. customevaporated

Sources & evidence

ORD record
ord-4a5d2103d978412ea3f2082c07f9c2ba
Source dataset
uspto-grants-1976_04
Patent number
US03952101

Reaction notes

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