反应详情

Sodium (70 mg.) was dissolved in dry methanol (5 ml.), and to the resulting solution of sodium methoxide (about 166 mg,) was added 2α,3α-epoxy-5α-pregnane-11,20-dione (100 mg). The solution was refluxed for 5 days, then water was added, and the mixture was neutralised with dilute hydrochloric acid and extracted into chloroform. The extract was dried over sodium sulphate and evaporated to a brown oil which was purified by preparative TLC in ethyl acetate/petrol (1/1). The title compound was recrystallised from ethyl acetate/petrol (21 mg).

1. temperatureThe solution was refluxed for 5 days
2. extractionextracted into chloroform
3. dry with materialThe extract was dried over sodium sulphate
4. customevaporated to a brown oil which
5. customwas purified by preparative TLC in ethyl acetate/petrol (1/1)
6. customThe title compound was recrystallised from ethyl acetate/petrol (21 mg)