Dichloromethane → 1175-97-9

HRID 1606428Notes

Reaction equation

HRID 1606428 reaction equation
Cl[CH2:2]Cl.[CH3:4][C:5]1([CH3:27])[S:9][C@@H:8]2[C@H:10]([NH:13][C:14]([C@H:16]([NH2:23])[C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)=[O:15])[C:11](=[O:12])[N:7]2[C@H:6]1[C:24]([OH:26])=[O:25].O.O.O.S([O-])([O-])(=O)=O.[Mg+2]>C(N(CC)CC)C>[CH3:4][C:5]1([CH3:27])[S:9][C@@H:8]2[C@H:10]([NH:13][C:14]([C@H:16]([NH2:23])[C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[O:15])[C:11](=[O:12])[N:7]2[C@H:6]1[C:24]([OH:26])=[O:25].[CH2:11]([N:7]([CH2:6][CH3:24])[CH2:8][CH3:2])[CH3:10]

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 23565Ampicillin TrihydrateHCID 24083Sulfuric acid magnesium salt (1:1)

Product 1

HCID 129189941175-97-9

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

In 60 ml. of dichloromethane was suspended 4.03 g. of ampicillin trihydrate and after adding to the solution 2.1 ml. of triethylamine and 4.0 g. of magnesium sulfate, the mixture was stirred for 30 minutes at room temperature. Then, by filtering off the magnesium sulfate, a dichloromethane solution of ampicillin triethylamine salt was obtained.

Workup

  1. filtrationThen, by filtering off the magnesium sulfate

Sources & evidence

ORD record
ord-383c4d318b3342039220e76d69e57976
Source dataset
uspto-grants-1976_04
Patent number
US03953428

Reaction notes

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