Hydrochloric Acid → HCID 138413, compound

HRID 1606495Notes

Reaction equation

HRID 1606495 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][CH:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)O)[CH:2]=1.Cl>C(O)(=O)C>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]=[CH:8][C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH:2]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 2383381-phenyl-2-pyridin-3-ylethanol

Product 1

HCID 138413HCID 138413, compoundYield 71.5%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of crude 2-(3-pyridyl)-1-phenylethanol (20 g), glacial acetic acid (200 ml) and concentrated HCl (50 ml) is refluxed for 16 hours, then evaporated to dryness in vacuo. The oily hydrochloride is taken up in water, extracted with ether and methylene chloride, and then liberated with bicarbonate. Extraction (CH2Cl2) and drying (K2CO3) affords 13 g of β-(3-pyridyl)styrene.

Workup

  1. temperatureis refluxed for 16 hours
  2. customevaporated to dryness in vacuo
  3. extractionextracted with ether and methylene chloride
  4. extractionExtraction (CH2Cl2)
  5. dry with materialdrying (K2CO3)

Sources & evidence

ORD record
ord-dcdf81f575f14605b562cd3fe9157e7a
Source dataset
uspto-grants-1976_04
Patent number
US03953434

Reaction notes

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