Anisole → HCID 21543499, compound

HRID 1606506Notes

Reaction equation

HRID 1606506 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH2:11][CH:12]([CH:14]1[O:18][CH2:17][CH2:16][O:15]1)[CH3:13].C1(OC)C=CC=CC=1.[F:27][C:28]1[CH:33]=[CH:32][C:31](I)=[CH:30][CH:29]=1.C(=O)([O-])[O-].[Na+].[Na+]>[Cu]>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([C:31]1[CH:32]=[CH:33][C:28]([F:27])=[CH:29][CH:30]=1)[CH:6]=[C:5]2[CH2:11][CH:12]([CH:14]1[O:18][CH2:17][CH2:16][O:15]1)[CH3:13]

Participants

6

Reactant 4

HCID 7519AnisoleHCID 96054-FluoroiodobenzeneHCID 10340Sodium CarbonateHCID 21543497HCID 21543497, compound

Product 1

HCID 21543499HCID 21543499, compound

Reagents, catalysts & solvents 1

HCID 23978CopperCatalyst

Procedure

A mixture of 15g (0.067 mole) of 5-chloro-3-[2-(1,3-dioxolan-2-yl)propyl] indole, 225 ml of anisole, 30g (0.135 mole) of 4-fluoroiodobenzene, 30g of copper powder and 60g of dry sodium carbonate are heated to reflux for 96 hours.

Workup

  1. temperatureare heated
  2. temperatureto reflux for 96 hours

Sources & evidence

ORD record
ord-606efb4bfb00465a93789e308a8bdb93
Source dataset
uspto-grants-1976_04
Patent number
US03953442

Reaction notes

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