反应详情

0.052 mole of 1-(2-chlorophenyl)-3-(2-hydroxyiminopropyl)indole is dissolved in 150 ml of dry tetrahydrofuran. 6 gms of lithium aluminium hydride are slowly added whilst refluxing for 3.5 hours. The reaction mixture is then poured on to a mixture of ice and ammonia and the product extracted with ether. The ethereal extract is treated with an N hydrochloric acid solution. The latter is then rendered alkaline with N soda solution. The turbid substance formed is extracted with ether, washed with water and dried. On removing the solvent the primary amine is obtained which, after recrystallisation from di-isopropyl ether, had a melting point of 79°C.

1. temperaturewhilst refluxing for 3.5 hours
2. extractionthe product extracted with ether
3. extractionThe ethereal extract
4. additionis treated with an N hydrochloric acid solution
5. customThe turbid substance formed
6. extractionis extracted with ether
7. washwashed with water
8. customdried
9. customOn removing the solvent the primary amine
10. customis obtained which
11. customafter recrystallisation from di-isopropyl ether