Triethylamine → HCID 178460115, compound

HRID 1606553Notes

Reaction equation

HRID 1606553 reaction equation
[NH:1]=[C:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[SH:4](=[O:17])([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[NH:3]1.[C:18](Cl)(=[O:21])[CH2:19][CH3:20].C(N(CC)CC)C>C(Cl)(Cl)Cl>[C:18]([N:1]=[C:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[SH:4](=[O:17])([C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)[NH:3]1)(=[O:21])[CH2:19][CH3:20]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 62324Propionyl chlorideHCID 178509313HCID 178509313, compound

Product 1

HCID 178460115HCID 178460115, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

From 12 g. 3-imino-1-phenyl-3H-1,2-benzisothiazole-1-oxide, 5 g. propionyl chloride and 6.6 g. triethylamine in chloroform, there is obtained, after heating under reflux for 3 hours and then working up the reaction mixture in the usual manner, the desired 3-(propionyl-imino)-1-phenyl-3H-1,2-benzisothiazole-1-oxide which, after recrystallisation from ethyl acetate, melts at 170°C.

Workup

  1. temperatureafter heating
  2. temperatureunder reflux for 3 hours
  3. customthe desired 3-(propionyl-imino)-1-phenyl-3H-1,2-benzisothiazole-1-oxide which, after recrystallisation from ethyl acetate, melts at 170°C.

Sources & evidence

ORD record
ord-6f0d2aeb73354c8e9a625681576aeaa5
Source dataset
uspto-grants-1976_04
Patent number
US03953464

Reaction notes

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