反应详情

A solution of 1.6 g. salicylic acid chloride in 5 cc. tetrahydrofuran is added dropwise, while stirring, to a solution of 1.8 g. 3-imino-1-methyl-3H-1,2-benzisothiazole-1-oxide and 1.2 g. triethylamine in 50 cc. tetrahydrofuran. The reaction mixture is stirred overnight at ambient temperature, thereafter poured into water and the precipitate obtained is filtered off with suction. There is thus obtained 3-(salicyloylimino)-1-methyl-3H-1,2-benzisothiazole-1-oxide which, after recrystallisation from ethanol, melts at 168° - 169°C.

1. stirringThe reaction mixture is stirred overnight at ambient temperature
2. customthe precipitate obtained
3. filtrationis filtered off with suction
4. customafter recrystallisation from ethanol, melts at 168° - 169°C.