反应详情

N-tert-butyl-5-methylisoxazolium perchlorate (120 g.; 0.005 mole) is added to a solution of 2-furfurylamino-4-chloro-5-methylsulfonylbenzoic acid (1.65 g.; 0.005 mole) and triethylamine (0.7 ml.) in dimethylformamide (15 ml.). The resulting solution is allowed to stir at room temperature for 2 hours, and then diluted with H2O (75 ml.). The white solid which precipitates is collected and dried, yield 2.4 g. (crude), m.p. 140°-145° C. Recrystallization from butyl chloride yields N-tert-butyl-3-(2-furfurylamino-4-chloro-5-methylsulfonylbenzoyloxy)crotonamide, m.p. 148.5°-150° C. (dec. with eff.).

1. customThe white solid which precipitates
2. customis collected
3. customdried
4. customRecrystallization from butyl chloride