Thionyl Chloride → HCID 21544131, compound

HRID 1606630Notes

Reaction equation

HRID 1606630 reaction equation
[I:1][C:2]1[C:10]([C:11]([NH:13][CH3:14])=[O:12])=[C:9]([I:15])[C:8]([NH:16][C:17](=[O:21])[CH2:18][O:19][CH3:20])=[C:7]([I:22])[C:3]=1[C:4](O)=[O:5].S(Cl)([Cl:25])=O>CN(C)C(=O)C>[I:1][C:2]1[C:10]([C:11]([NH:13][CH3:14])=[O:12])=[C:9]([I:15])[C:8]([NH:16][C:17](=[O:21])[CH2:18][O:19][CH3:20])=[C:7]([I:22])[C:3]=1[C:4]([Cl:25])=[O:5]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 21544128HCID 21544128, compound

Product 1

HCID 21544131HCID 21544131, compound

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

A solution of 2,4,6-triiodo-5-methoxyacetamido-N-methylisophthalamic acid in N,N-dimethylacetamide is treated with an excess of thionyl chloride. After the reaction, the excess thionyl chloride is removed by evaporation and the product is suitable for use as intermediate in situ.

Workup

  1. customAfter the reaction
  2. customthe excess thionyl chloride is removed by evaporation

Sources & evidence

ORD record
ord-4f7bf19807f5496998875539a67e61d3
Source dataset
uspto-grants-1976_04
Patent number
US03953497

Reaction notes

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