Acetyl chloride → HCID 21427248, compound

HRID 1606665Notes

Reaction equation

[CH3:1][NH:2][C:3](=[O:23])[CH:4](CO)[NH:5][C:6](=[O:20])[C:7]1[C:12]([I:13])=[C:11]([NH2:14])[C:10]([I:15])=[C:9]([C:16]([OH:18])=[O:17])[C:8]=1[I:19].[C:24](Cl)(=[O:26])[CH3:25].[CH3:28]C(N(C)C)=O>>[CH3:1][NH:2][C:3](=[O:23])[CH2:4][N:5]([C:6](=[O:20])[C:7]1[C:12]([I:13])=[C:11]([NH:14][C:24](=[O:26])[CH3:25])[C:10]([I:15])=[C:9]([C:16]([OH:18])=[O:17])[C:8]=1[I:19])[CH3:28]

Participants

Reactant 3

HCID 6367Acetyl chloride

HCID 31374Dimethylacetamide

HCID 21427255HCID 21427255, compound

Product 1

HCID 21427248HCID 21427248, compound

Procedure

Analogously to Example 3, 71.5 g. (74.5%) of N-3-carboxy-5-acetamido-2,4,6-triiodobenzoyl)-sarcosine methylamide, m.p. 270°-271° C. (under decomposition) is obtained from 90 g. (0.14 mole) of N-(3-carboxy-5-amino-2,4,6-triiodobenzoyl)-sarcosine methylamide (IV e), m.p. 238°-240° C. (decomposition) in 170 ml. of dimethylacetamide and 27.4 ml. of acetyl chloride.

Sources & evidence

ORD record: ord-3947b44e9815438f9f9080261a88118c
Source dataset: uspto-grants-1976_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03953501

Reaction notes

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