Acetic Acid → HCID 70616871, compound

HRID 1606703Notes

Reaction equation

HRID 1606703 reaction equation
[C:1]([NH:9][C@@H:10]([C:16]([OH:18])=[O:17])[CH2:11][CH2:12][C:13]([OH:15])=[O:14])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(O)(=O)C.[CH:23]1([NH2:33])[C:32]2[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=2)[CH2:26][CH2:25][CH2:24]1>O>[C:1]([NH:9][C@@H:10]([C:16]([OH:18])=[O:17])[CH2:11][CH2:12][C:13]([OH:15])=[O:14])(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1.[C@@H:23]1([NH2:33])[C:32]2[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=2)[CH2:26][CH2:25][CH2:24]1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 180661,2,3,4-Tetrahydro-1-naphthylamineHCID 11207465(+)-N-Benzoylglutamic acid

Product 1

HCID 70616871HCID 70616871, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
55 °C

Procedure

A stirred mixture of 284 grams (1.13 moles) of (R)-(+)-N-benzoylglutamic acid, 136 grams (2.26 moles) of acetic acid, and 2 liters of water is heated to 55° C. to give a solution. To this stirred solution is added 333 grams (2.26 moles) of racemic 1,2,3,4-tetrahydro-1-naphthylamine.

Workup

  1. customto give a solution

Sources & evidence

ORD record
ord-adf8a74f07714f5cb1805267e9abaa74
Source dataset
uspto-grants-1976_04
Patent number
US03953506

Reaction notes

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