Acetic Acid → HCID 21544463, compound

HRID 1606763Notes

Reaction equation

HRID 1606763 reaction equation
[CH2:1]([S:10][C:11]1[CH:12]=[C:13]([CH:17]=[C:18]([C:20]([F:23])([F:22])[F:21])[CH:19]=1)[C:14]([OH:16])=[O:15])[C:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)=[O:3].OO.C(O)(=[O:28])C>O>[CH2:1]([S:10]([C:11]1[CH:12]=[C:13]([CH:17]=[C:18]([C:20]([F:23])([F:21])[F:22])[CH:19]=1)[C:14]([OH:16])=[O:15])=[O:28])[C:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)=[O:3]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 784Hydrogen PeroxideHCID 215444803-[(2-Oxo-2-phenylethyl)thio]-5-(trifluoromethyl)benzoic acid

Product 1

HCID 21544463HCID 21544463, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 2.6 g. (7.5 m moles) of 3-phenacylthio-5-trifluoromethylbenzoic acid and .75 ml. of 30% hydrogen peroxide in 15 ml. of acetic acid is heated on a steam bath for 1 hour, after which the reaction mixture is cooled and diluted with water to the turbidity point. The crystalline product which forms on standing is filtered, 1.0 g., m.p. 148°-151° C., and finally recrystallized from acetone-isopropyl ether, 850 mg., m.p. 154°-155° C.

Workup

  1. temperatureafter which the reaction mixture is cooled
  2. filtrationis filtered
  3. custom, m.p. 148°-151° C., and finally recrystallized from acetone-isopropyl ether, 850 mg

Sources & evidence

ORD record
ord-b757dd89d7a94a7da2931c597d24a457
Source dataset
uspto-grants-1976_04
Patent number
US03953595

Reaction notes

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