Hydrochloric Acid → 2-(beta-Hydroxyethyl)amino-4-(beta-hydroxyethyl)amino-6-(beta-hydroxyethyl)aminonitrobenzene
Reaction equation
[OH:1][CH2:2][CH2:3][NH:4][C:5]1[CH:10]=[C:9](Cl)[CH:8]=[C:7]([NH:12][CH2:13][CH2:14][OH:15])[C:6]=1[N+:16]([O-:18])=[O:17].[CH2:19]([CH2:21][NH2:22])[OH:20].Cl>>[OH:1][CH2:2][CH2:3][NH:4][C:5]1[CH:10]=[C:9]([NH:22][CH2:21][CH2:19][OH:20])[CH:8]=[C:7]([NH:12][CH2:13][CH2:14][OH:15])[C:6]=1[N+:16]([O-:18])=[O:17]Participants
4
Procedure
0.0072 mole (2 g) of 2-(β-hydroxyethyl)amino-6-(β-hydroxyethyl)amino-4-chloronitrobenzene, synthesized in stage 1 of example 2, was heated at 100°-110° C. with 6 ml of ethanolamine for 6 hours. The reaction medium was diluted with ice water then brought to neutrallity by addition of concentrated hydrochloric acid to precipitate out the desired product. After filtering and hot drying under vacuum in the presence of P2O5, it was recrystallized from 96° ethanol. It melted at 200° C.
Workup
- customto precipitate out the desired product
- filtrationAfter filtering
- dry with materialhot drying under vacuum in the presence of P2O5, it
- customwas recrystallized from 96° ethanol
Sources & evidence
- ORD record
- ord-392a6a096fe54f3890b1fdcbfecea432
- Source dataset
- uspto-grants-1989_09
- Patent number
- US04863482
Reaction notes
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