反应详情

3.90 g (11.5 mmol) of 4,5-dihydro-3-iodo-5-methyl-6H-imidazo[1,5-a][1,4]benzodiazepin-6-one was heated to boiling under reflux for 5 hours with 0.67 g (12 mmol) of propargyl alcohol, 70 mg of bis-(triphenylphosphine)-palladium(II) dichloride and 10 mg of copper(I) iodide in 30 ml of diethylamine. The solvent was then evaporated, the residue was taken up in methylene chloride, the solid was filtered off and rinsed with ethyl acetate. After drying there was obtained 4,5-dihydro-3-(3-hydroxy-1-propynyl)-5-methyl-6H-imidazo[1,5-a][1,4]benzodiazepin-6-one of melting point 240°-241°.

1. customThe solvent was then evaporated
2. filtrationthe solid was filtered off
3. washrinsed with ethyl acetate
4. customAfter drying there