Diethylamine → HCID 19851823, compound

HRID 1607088Notes

Reaction equation

HRID 1607088 reaction equation
C1(C(C2C=CC=CC=2)(C2C=CC=CC=2)[NH:8][CH2:9][CH2:10][S:11][C:12]([O:14]C2C=CC([N+]([O-])=O)=CC=2)=O)C=CC=CC=1.[CH2:36]([NH:38][CH2:39][CH3:40])[CH3:37].C(N(CC)CC)C.CC1C(=O)C2N3[C@@](OC)([C@H](COC(N)=O)C=2C(=O)C=1OC)[C@H]1N[C@H]1C3>CO>[CH2:36]([N:38]([CH2:39][CH3:40])[C:12]([S:11][CH2:10][CH2:9][NH2:8])=[O:14])[CH3:37]

Participants

6

Reactant 4

HCID 8021DiethylamineHCID 8471TriethylamineHCID 19972Mitomycin AHCID 15616513HCID 15616513, compound

Product 1

HCID 19851823HCID 19851823, compoundYield 60%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-diethylaminocarbonylthioethylamine (formate: 184 mg) was prepared by subjecting N-triphenylmethyl-2-paranitrophenoxycarbonylthioethylamine (500 mg) and diethylamine (316 μl) to the similar reactions to those described in References 2 and 4. The product was dissolved in anhydrous methanol (4 ml). To the solution were added triethylamine (174 μl) and mitomycin A (273 mg: 0.75 molar equivalent). The reaction solution was treated in a similar manner to that described in Example 1 to obtain Compound 4 (130 mg) in the form of grayish blue powders with a yield of 60%.

Workup

  1. additionThe reaction solution was treated in a similar manner to that

Sources & evidence

ORD record
ord-87b372aad00f4feaae0e0f37c3bb16de
Source dataset
uspto-grants-1989_09
Patent number
US04863935

Reaction notes

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