Triethylamine → HCID 54016037, compound

HRID 1607090Notes

Reaction equation

HRID 1607090 reaction equation
[CH3:1][NH:2][C:3]([S:5][CH2:6][CH2:7][NH2:8])=[S:4].C(N([CH2:14][CH3:15])CC)C.C[C:17]1[C:23](=O)[C:22]2N3[C@@:29](OC)([C@H:30]([CH2:31]OC(N)=O)[C:21]=2[C:19](=O)[C:18]=1OC)[C@H:28]1N[C@H:27]1[CH2:26]3>CO>[C:31]1([C:30]([C:21]2[CH:19]=[CH:18][CH:17]=[CH:23][CH:22]=2)([C:29]2[CH:28]=[CH:27][CH:26]=[CH:15][CH:14]=2)[NH:8][CH2:7][CH2:6][S:5][C:3]([NH:2][CH3:1])=[S:4])[CH:22]=[CH:23][CH:17]=[CH:18][CH:19]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 19972Mitomycin AHCID 54198635HCID 54198635, compound

Product 1

HCID 54016037HCID 54016037, compoundYield 44%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

N-triphenylmethyl-2-methylaminothiocarbonylthioethylamine (0.89 g) which was prepared by the method of Reference 5 was subjected to a similar reaction to that described in Reference 4 to prepare 2-methylaminothiocarbonylthioethylamine (crude formate: 223 mg). The product was dissolved in anhydrous methanol (7 L ml). Triethylamine (732 μl) and mitomycin A (316 mg: 0.8 molar equivalent) were added to the reaction solution which was then treated in a similar manner to that described in Example 1 to obtain Compound 25 (233 mg) in the form of grayish blue powders with a yield of 44%.

Workup

  1. customwas subjected to a similar reaction to
  2. additionwas then treated in a similar manner to that

Sources & evidence

ORD record
ord-6e398373baa740c4ab8ed5a538325a06
Source dataset
uspto-grants-1989_09
Patent number
US04863935

Reaction notes

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