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HRID1607228

反应详情

EQUATION

反应方程式

HRID 1607228 的结构方程式

REACTANTS

反应物

3
结构：CCN(CC)CC
HCID8471

Triethylamine

C6H15N

结构：O=C=Nc1ccc(C(F)(F)F)cc1
HCID73768

1-Isocyanato-4-(trifluoromethyl)benzene

C8H4F3NO

结构：COC(=O)C1(C)CNN=C1c1ccc(Cl)cc1.Cl
HCID19852122

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)C1(C)CN(C(=O)Nc2ccc(C(F)(F)F)cc2)N=C1c1ccc(Cl)cc1
HCID108039

Methyl 3-(4-chlorophenyl)-4-methyl-1-{[4-(trifluoromethyl)phenyl]carbamoyl}-4,5-dihydro-1H-pyrazole-4-carboxylate

C20H17ClF3N3O3

收率 95%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

3-(4-chlorophenyl)-4-carbomethoxy-4-methyl-4,5-dihydro-1H-pyrazole hydrochloride (Example P) (10 mmole), triethylamine (20 mmole), methylene chloride (30 ml) were added together and stirred for 10 minutes, whereon 10 mmole of 4-trifluoromethylphenyl isocyanate was added and after 30 minutes the resulting mixture was washed twice with water, dried with magnesium sulfate and concentrated giving a 95% yield of N-(4-trifluoromethylphenyl)-3-(4-chlorophenyl)-4-carbomethoxy-4-methyl-4,5-dihydro-1H-pyrazole-1-carboxamide. NMR data was consistent with the structure.

WORKUP

后处理

  1. additionwas added and after 30 minutes the resulting mixture
  2. washwas washed twice with water
  3. dry with materialdried with magnesium sulfate
  4. concentrationconcentrated