Water → HCID 14570909, compound

HRID 1607292Notes

Reaction equation

HRID 1607292 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([CH2:8][CH2:9][CH3:10])[C:5]([OH:11])=[CH:4][C:3]=1[OH:12].[CH2:13]1N2CN3CN(C2)CN1C3.[OH2:23]>FC(F)(F)C(O)=O>[Cl:1][C:2]1[C:3]([OH:12])=[C:4]([C:5]([OH:11])=[C:6]([CH2:8][CH2:9][CH3:10])[CH:7]=1)[CH:13]=[O:23]

Participants

5

Reactant 3

HCID 962WaterHCID 4101HexamethylenetetramineHCID 2381734-chloro-6-propylbenzene-1,3-diol

Product 1

HCID 14570909HCID 14570909, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

To a solution of 2-chloro-4-propyl-1,5-dihydroxybenzene (from Step a, 243 mg, 1.3 mmol) in 10 mL trifluoroacetic acid was added 1 g of hexamine. The mixture was refluxed for 20 h. Water was added and the mixture was extracted with ethyl acetate. Chromatography of the concentrated organic extracts gave the title compound.

Workup

  1. temperatureThe mixture was refluxed for 20 h
  2. extractionthe mixture was extracted with ethyl acetate

Sources & evidence

ORD record
ord-5313288abca543b3812b35780c5d7e4a
Source dataset
uspto-grants-1989_09
Patent number
US04863958

Reaction notes

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