反应详情

A mixture of 3'-chloro-4'-nitroacetophenone (3.0 g), phenol (2.5 g), and potassium carbonate (4.0 g) in xylene (70 ml) was refluxed for 8 hours. The insoluble was filtered off and the filtrate was concentrated under reduced pressure. The oily residue (2.7 g) was subjected to column chromatography on silica gel (70 g) eluting with toluene. The fractions containing the desired compound were combined and concentrated under reduced pressure to give crystals of 4'-nitro-3'-phenoxyacetophenone (1.7 g).

1. temperaturewas refluxed for 8 hours
2. filtrationThe insoluble was filtered off
3. concentrationthe filtrate was concentrated under reduced pressure
4. washeluting with toluene
5. additionThe fractions containing the desired compound
6. concentrationconcentrated under reduced pressure