反应详情

温度

110 °C

A mixture of 4'-cyano-2'-(2,4-difluorophenoxy)methanesulfonanilide (2.1 g), sodium azide (0.5 g) and ammonium chloride (0.43 g) in N,N-dimethylformamide (10 ml) was stirred for 6 hours at 110° C. The mixture was poured into a mixture of ice and diluted hydrochloric acid, and extracted with ethyl acetate. The extract was washed with water, dried and concentrated in vacuo. The residual crystals were recrystallized from ethyl acetate to give colorless crystals of 2'-(2,4-difluorophenoxy)-4'-(5-tetrazolyl)methanesulfonanilide (2.3 g).

1. extractionextracted with ethyl acetate
2. washThe extract was washed with water
3. customdried
4. concentrationconcentrated in vacuo
5. customThe residual crystals were recrystallized from ethyl acetate